Abstract: Objective This study aimed to investigate the epidemiological and clinical characteristics of psittacosis in Fuyang District and provide evidence for clinical diagnosis, treatment, prevention and control. Methods We collected epidemiological and clinical data of psittacosis cases residing in Fuyang District from September 2020 to February 2025. Descriptive epidemiological methods were applied to analyze temporal-spatial-demographic distributions, exposure histories, clinical features and laboratory results, combined with environmental surveillance and follow-up data. Results The sex ratio of 16 psittacosis cases was 1:1, with an incidence rate of 0.57/100 000 for both males and females. The mean age was 59.88 ± 10.66 years old, and the highest incidence rates were in the 70~ and 60~ age groups, at 1.41/100 000 and 1.30/100 000 respectively. 14 cases had a history of poultry exposure (87.50%). The predominant symptoms included high fever (15, 93.75%), cough (11, 68.75%), sputum production (9, 56.25%) and chills (8, 50.00%). All cases showed elevated levels of C-reactive protein (CRP) and D-dimer with radiographic evidence of pneumonia on computed tomography (CT) scans. 87.50% (14/16) cases showed increased neutrophil percentage (NE%) and 93.75% (15/16) cases showed decreased lymphocyte percentage (LY%). The median time from onset to consultation was 4 days, the median time from onset to diagnosis was 9.5 days, and the median time of hospitalization was 9 days. The NE%, CRP, days between onset and diagnosis, days between onset and medication, and days of hospitalization in the severe group were all higher than those in the non-severe group. All cases resolved with discharge, and over 50% were treated with omadacycline following confirmed diagnosis. Conclusion Most psittacosis cases reported definitive poultry exposure histories in Fuyang District of Hangzhou. Early diagnosis and early treatment are critical for preventing disease progression to severe stages.