Abstract: Objective This study aimed to analyze and investigate the epidemiological and etiological characteristics of suspected foodborne disease cases caused by Salmonella infection in Taizhou City of Zhejiang Province from 2020 to 2024, so as to provide a scientific basis for the prevention and control of Salmonella infections. Methods Descriptive statistical methods were used to analyze the reported data for suspected foodborne disease cases caused by Salmonella infection and their epidemiological characteristics. Results From 2020 to 2024, a total of 21751 suspected foodborne disease cases with biological samples were reported in Taizhou City of Zhejiang Province, with 2 502 strains of Salmonella detected, yielding an average detection rate of 11.50%. The detection rate of Salmonella was the highest in 2024 (14.78%). The seasonal distribution indicated higher detection rates in the second and third quarters (accounting for 77.26%). The age distribution showed the highest detection rate in children aged 0-2 years old (51.78%), and the coastal districts and counties had a higher detection rate (14.61%). There was no statistically significant difference between males and females. A total of 125 Salmonellarotypes were isolated, among which the main ones were Salmonella Typhimurium (48.48%), Salmonella Enteritidis (12.15%), and Salmonella London (8.39%). There were differences in the food category association profiles among Salmonella serotypes with different predominance. Conclusion In Taizhou City, the detection rate of Salmonella in foodborne diseases was relatively high in coastal districts and counties. Children aged 0-4 years old, especially those under 2 years old, were high-risk groups for Salmonella infection. The main dominant serotype was Salmonella Typhimurium; meat and meat-related products, grain products, aquatic products as well as infant food were the main high-risk foods. It is suggested that key supervision should be implemented on critical links such as food processing, and targeted food safety and health education should be strengthened for key populations, so as to achieve early warning and effective control of Salmonella infections.