上海市松江区孕妇麻疹和风疹抗体水平监测

胡塔静; 朱祺; 陈文花; 沈金花; 顾士康; 沈静雯; 陆红梅

doi:10.19428/j.cnki.sjpm.2017.07.006

上海市松江区孕妇麻疹和风疹抗体水平监测

Surveillance of measles and rubella antibodies levels of pregnant women in Songjiang District of Shanghai

摘要

摘要:
目的了解上海市松江区孕妇麻疹和风疹IgG抗体水平，为预防初免前婴儿麻疹、风疹及新生儿先天性风疹综合征的发生提供科学的免疫策略。
方法分别于2013年5—8月和2014年4—6月，按照就诊顺序用随机数字法随机抽取松江区妇幼保健院和第一人民医院产科15~岁、25~岁、35~岁3个年龄组600名健康孕妇进行监测，采用酶联免疫吸附试验(ELISA)检测每名孕妇血清的麻疹和风疹IgG抗体水平，采用SAS 9.2软件对相关数据进行统计学分析。
结果600名健康孕妇的麻疹IgG抗体几何平均浓度和阳性率分别为885.58 mIU/mL和86.50%，风疹IgG抗体几何平均浓度和阳性率分别为197.85 IU/mL和82.17%；非本市户籍孕妇的麻疹和风疹抗体水平均高于本市户籍孕妇，各年龄组间孕妇麻疹和风疹抗体水平差异无统计学意义(P均＞0.05)。
结论为控制初免前婴儿麻疹、风疹的发病及新生儿先天性风疹综合征的发生，应在育龄期妇女中开展含麻疹和风疹成分疫苗的补种。

Abstract:
ObjectiveTo explore serum levels of measles and rubella IgG antibodies among pregnant women in order to provide scientific evidence for the prevention strategy of measles, rubella among infants before initial immune months and congenital rubella syndrome (CRS) among neonatus.
MethodsA total of 600 healthy pregnant women were randomly selected of 15 to 24 years, 25 to 34 years and 35 to 44 years in maternity hospitals of Songjiang District from May to August 2013 and April to June 2014, with venous blood collected and serum measles and rubella IgG antibodies measured by using enzyme-linked immunosorbent assay (ELISA).
ResultsThe survey on the 600 healthy pregnant women showed that geometric mean concentration and positive rate of measles IgG antibodies were 885.58 mIU/mL and 86.50% respectively, those of rubella IgG antibodies were 197.85 IU/mL and 82.17% respectively. Measles and rubella antibodies levels of pregnant women among different age groups did not vary significantly, however, migrant population's measles and rubella antibodies levels were both higher than those of the locals.
ConclusionIn order to prevent measles, rubella and CRS, it is necessary to carry out supplemental vaccination with measles and rubella ingredients for women of childbearing age.

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