黄胸鼠对溴敌隆的抗药性试验观察

朱伟; 王永鸣; 刘曜

doi:10.19428/j.cnki.sjpm.2018.18873

黄胸鼠对溴敌隆的抗药性试验观察

Experimental observation on resistance to bromadiolone with Rattus tanezumi

摘要

摘要:
目的研究黄胸鼠对溴敌隆的抗药性，为控制黄胸鼠的繁殖提供科学依据。
方法在上海市徐汇区现场捕获黄胸鼠，进行无选择性摄毒试验，首先喂食足量的无药物前饵2 d，然后喂食0.005%溴敌隆毒饵9 d，最后正常饲养16 d，观察动物的致死食药天数(LFP)等指标。
结果该地区黄胸鼠对溴敌隆的抗性发生率为16.67%；不同性别黄胸鼠对溴敌隆的敏感性差异无统计学意义；LFP₅₀、LFP₉₈和LFP₉₉及其95%可信区间分别为6.08(5.71~6.48) d、14.20(12.21~17.63) d和15.89(13.44~20.23) d。
结论该地区的黄胸鼠对溴敌隆的抗性发生率高于上海市整体水平，防控人员应采用药物轮换或引入其他防制方法，并广泛开展爱国卫生运动，控制鼠密度。

Abstract:
ObjectiveTo study the resistance of Rattus tanezumi to bromadiolone in Xuhui and provide laboratory evidence for the control of Rattus tanezumi.
MethodsThe in-taking toxicity was tested by unselective method in Rattus tanezumi; first, they were fed with no drug bait for 2 days, then 0.005% Bromadiolone bait for 9 days, and finally no drug bait for 16 days, so as to observe indexes as the number of days of lethal drug consumption (LFP).
ResultsThere was no significant difference found between male and female Rattus tanezumi in their susceptibility to bromadiolone. The LFP₅₀, LFP₉₈, LFP₉₉ and their 95% confidence interval was 6.08 (5.71－6.48) days, 14.20 (12.21－17.63) days, 15.89 (13.44－20.23) days respectively.
ConclusionThe incidence of resistance to bromadiolone with Rattus tanezumi in Xuhui District was 16.67%, higher than the average level in Shanghai.In order to control rat density, PCO staff should use drug rotation or other methods of prevention and control, and extensively carry out patriotic sanitation campaign.

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