血清淀粉样蛋白A、C反应蛋白和降钙素原联合检测在新生儿感染诊断中的应用

胡爱星; 李情操

doi:10.19428/j.cnki.sjpm.2019.18428

血清淀粉样蛋白A、C反应蛋白和降钙素原联合检测在新生儿感染诊断中的应用

Application of SAA, CRP and PCT in diagnosis of neonatal infections

摘要

摘要:
目的探讨血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)及降钙素原(PCT)检测在新生儿感染性疾病早期诊断中的价值。
方法分别采用ELISA和化学发光方法检测30例新生儿败血症和34例病毒感染患儿血清SAA、CRP、PCT水平，并与正常对照组新生儿进行比较。
结果败血症组血清SAA、CRP、PCT水平与对照组比较差异均有统计学意义(P < 0.01)；病毒感染组中血清SAA水平与对照组比较差异有显著统计学意义(P < 0.01)，而CRP水平与对照组比较差异有统计学意义(P < 0.05)。败血症组血清SAA、CRP、PCT阳性率分别为96.7%、73.3%、90.0%；病毒感染组血清SAA、CRP、PCT阳性率分别为100.0%、29.4%、8.8%，其中SAA与CRP和PCT比较差异均有显著统计学意义(P < 0.01)。
结论血清SAA、CRP、PCT水平的联合连续检测可以作为新生儿感染性疾病早期诊断和判断病情的客观指标，有助于鉴别细菌感染与病毒感染。

Abstract:
ObjectiveTo investigate the value of serum amyloid A (SAA), C-reactive protein (CRP) and procalcitonin (PCT) in early diagnosis of neonatal infective diseases.
MethodsThe levels of SAA, CRP and PCT in 30 cases of neonates with neonatal septicemia and 34 cases of virus infection were detected by ELISA and chemiluminescence respectively, and compared with the normal control group.
ResultsThere were statistically significant differences in serum SAA, CRP and PCT levels between the septicemia group and the control group (P < 0.01);there were statistically significant differences in serum SAA levels between the viral infection group and the control group (P < 0.01), while CRP levels was statistically significant different as compared with those of the control (P < 0.05).The serum SAA, CRP and PCT positive rates were 96.7%, 73.3% and 90% respectively in the septicemia group, and 100%, 29.4% and 8.8% respectively in the viral infection group.There were statistically significant differences between SAA, CRP and PCT (P < 0.01).
ConclusionThe combined detection of serum SAA, CRP and PCT can be used as an objective index for early diagnosis and judgement of neonatal infective diseases and help to differentiate bacterial and viral infections.

HTML全文

参考文献(14)

施引文献

资源附件(0)