ObjectiveTo investigate the distribution and changes of the total IgE and allergen specific IgE in children, and to provide the evidences for the prevention and control of children′s allergic diseases.

MethodsThe total IgE and allergen specific IgE were detected in 338 children from the Maternity and Child Health Care Hospital of Huzhou from August 2017 to February 2018.The total IgE was determined by colloidal gold method and the specific IgE by immunoblotting.

ResultsAmong the 338 children detected, 56.51%(191/338) were TIgE positive; specific IgE antibody were positive in 124 children, accounting for 36.69%(124/338), 61.29% of them for a single material allergy, 38.71% for 2 or more allergy; There was no significant difference between different sexes in total IgE and allergen specific IgE(P>0.05);there were 63 positive cases in inhalation allergens specific IgE; the positive rate was 18.64%(63/338);inhalation allergens were mainly house dust mites; 136 positive cases were found in food allergens specific IgE, and the positive rate was 40.24%(136/338);food allergens mainly consisted of egg white and milk; with the increase of age, gradually increased were the total IgE and inhalation allergens, and gradually reduced were food allergens.The differences were statistically significant(P < 0.05).

ConclusionDust mite, egg white and milk are the most common allergens found with infants, and early prevention should focus on food allergy.With the increase of age, we need to be wary of inhalation allergens which cause immediate hypersensitivity reactions; detection of serum total IgE and allergen specific IgE is conducive to understanding the allergic state, and it can contribute to prevention, diagnosis and treatment of allergic diseases in children.