高血压患者血同型半胱氨酸与急性心脑血管事件相关性的巢式病例对照研究

严青华; 王玉恒; 杨沁平; 程旻娜

doi:10.19428/j.cnki.sjpm.2019.18933

高血压患者血同型半胱氨酸与急性心脑血管事件相关性的巢式病例对照研究

Nested case-control study on the correlation between homocysteine and acute cardiovascular and cerebrovascular events in hypertension patients

摘要

摘要:
目的探讨高血压患者血同型半胱氨酸水平与急性心脑血管事件发生的关系。
方法采用巢式病例对照的研究方法从随访4年的13 209例新发高血压患者中观察到197例发生过急性心脑血管事件，采用病例对照1 ︰ 1进行匹配，利用卡方检验、配对t检验、条件logistics回归对数据进行分析。
结果研究对象的血同型半胱氨酸几何均数为14.63 μmol/L，男性(16.07 μmol/L)高于女性(13.02 μmol/L)，F=20.67，P < 0.01。病例组血同型半胱氨酸几何均数为15.07 μmol/L，与对照组(14.20 μmol/L)间差异无统计学意义(t=0.53，P=0.60)。进一步控制多种混杂因素后，血同型半胱氨酸与心脑血管急性事件间无关联。
结论血同型半胱氨酸与急性心脑血管事件间的关系并不是很明确，需对此进行进一步的研究。

Abstract:
ObjectiveTo explore the relationship between homocysteine(Hcy) and acute cardiovascular and cerebrovascular events in patients with hypertension.
MethodsBy nested case control method 197 cases of acute cardiovascular and cerebrovascular events among 13 209 cases of new developed hypertension were observed; the case control was matched by 1 ︰ 1.The data were analyzed by chi square test, paired t test, and unconditional logistics regression.
ResultsAmong the subjects in the study, the geometric mean of homocysteine was 14.63 μmol/L, the male was 16.07 μmol/L, which was higher than that of the female (13.02 μmol/L) (F=20.67, P < 0.001).The geometric mean of homocysteine in the case group was 15.07 μmol/L, and there was no significant difference (t=0.53, P=0.60) between case group and control group (14.63 μmol/L) in this regard.There was no correlation between Hcy and acute cardiovascular and cerebrovascular events after further control of multiple confounding factors.
ConclusionThe relationship between Hcy and acute cardiovascular and cerebrovascular events is not very clear.Further study is needed.

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