李晓军, 赵世莹, 杨佳平, 朱江, 张迈月, 张月娟. 上海市某区老年人接种23价肺炎球菌多糖疫苗效果评价[J]. 上海预防医学, 2019, 31(4): 259-263. DOI: 10.19428/j.cnki.sjpm.2019.19319
引用本文: 李晓军, 赵世莹, 杨佳平, 朱江, 张迈月, 张月娟. 上海市某区老年人接种23价肺炎球菌多糖疫苗效果评价[J]. 上海预防医学, 2019, 31(4): 259-263. DOI: 10.19428/j.cnki.sjpm.2019.19319
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LI Xiao-jun, ZHAO Shi-ying, YANG Jia-ping, ZHU Jiang, ZHANG Mai-yue, ZHANG Yue-juan. PPV-23 vaccination evaluation of the elderly in a district of Shanghai[J]. Shanghai Journal of Preventive Medicine, 2019, 31(4): 259-263. DOI: 10.19428/j.cnki.sjpm.2019.19319
Citation: LI Xiao-jun, ZHAO Shi-ying, YANG Jia-ping, ZHU Jiang, ZHANG Mai-yue, ZHANG Yue-juan. PPV-23 vaccination evaluation of the elderly in a district of Shanghai[J]. Shanghai Journal of Preventive Medicine, 2019, 31(4): 259-263. DOI: 10.19428/j.cnki.sjpm.2019.19319
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上海市某区老年人接种23价肺炎球菌多糖疫苗效果评价

PPV-23 vaccination evaluation of the elderly in a district of Shanghai

    摘要
  • 摘要:
    目的研究老年人接种23价肺炎球菌多糖疫苗(23-valent pneumococcal polysaccharide vaccine，PPV-23)后，血清抗体水平的变化情况。
    方法采用多阶段随机抽样方法，选择200名60岁及以上沪籍老人接种PPV-23疫苗，分别对接种前、接种后1个月、3个月和6个月血清抗体水平进行检测，并比较抗体水平。
    结果疫苗接种前，肺炎球菌抗体阳性率为9.00%，吸烟的老年人肺炎球菌抗体阳性率高于不吸烟者(χ2=5.81，P=0.02)，有哮喘病史者亦显著高于无哮喘病史者(χ2=2.40，P=0.01)。PPV-23疫苗接种后1个月、3个月和6个月，老年人肺炎球菌抗体阳性率分别为44.50%、60.50%和50.50%，高于接种前。接种后3个月阳性率最高，高于接种后1个月(χ2=21.33，P < 0.001)，亦高于接种后6个月(χ2=10.00，P=0.002)；接种后1个月抗体阳性率与接种后6个月差异无统计学意义(χ2=2.77，P=0.10)。未有证据支持年龄、性别、文化程度、抽烟、锻炼、是否有相关疾病等因素对肺炎球菌抗体水平有影响。
    结论老年人接种PPV-23疫苗后可产生特异性抗体，且可维持6个月。

     

    Abstract:
    ObjectiveTo investigate the changes of serum antibody levels in the elderly after vaccination with 23-valent pneumococcal polysaccharide vaccine (PPV-23).
    MethodsA multi-stage random sampling method was adopted to select 200 elderly native people over 60 years old from Shanghai who were vaccinated with PPV-23 vaccine.Serum antibody levels were detected and compared before and after vaccination at 1 month, 3 months and 6 months.
    ResultsA total of 200 elderly people were investigated.Before vaccination, the positive rate of pneumococcal antibody was 9.00%.The positive rate of pneumococcal antibody in smokers was higher than that in non-smokers (χ2=5.81, P=0.02) and in those with asthma history were also significantly higher than in those without asthma history (χ2=2.40, P=0.01).The positive rates of pneumococcal antibodies in the elderly were 44.50%, 60.50% and 50.50% respectively 1 month, 3 months and 6 months after pneumonia vaccination, which were significantly higher than those before vaccination.The highest positive rate was found at 3 months after vaccination, which was higher than that at 1 month after vaccination (χ2=21.33, P < 0.001), and significantly higher than that at 6 months after vaccination (χ2=10.00, P=0.002).There was no significant difference in the positive rate of antibody between 1 month and 6 months after vaccination (χ2=2.77, P=0.10).There was no evidence to support the influence of age, sex, education, smoking, exercise and related diseases on pneumonia vaccine antibody level.
    ConclusionPPV-23 vaccine can produce specific antibodies which can last for 6 months in the elderly.

     

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