Objective To study the risk management of pregnancy with severe special diseases.

Methods The relevant data on 181 women (< 28 weeks gestation) with severe special diseases reported from 2014 to 2016 in Shanghai city were analyzed retrospectively.

Results The incidence of pregnancy with severe special diseases rose from 2014-2016, the incidence of 2016 was significantly higher than that of 2014 (P < 0.01).The average age of 181 pregnant women with severe special diseases was (29.06±5.41) years old, and pregnant women over 35 years of age accounted for 16.02%.The proportion of pregnant women (over 35) with severe special diseases in 2016 increased compared with the previous two years.Among 181 pregnant women with severe special diseases, the proportion of non-household registration people(76.80%) was higher than that of Shanghai household registered women(23.20%), the pregnant women who temporarily lived in Shanghai(residence time < 6 months) accounted for 35.91%.The top three diseases of 181 pregnant women with severe special diseases were pregnancy with cardiopathy, pregnancy with blood diseases and pregnancy with diseases of the immune system.Among the 181 pregnant women with severe special diseases, 47 cases received rescue of severe pregnant (259.67‰), which was significantly higher than the incidence of critically ill pregnant women in Shanghai during 2014-2016 (2.31‰, 3.12‰, 3.31‰ for three years respectively, and the average 2.89‰).The hospitalization expenses were lower if pregnancy terminated within 13 weeks gestation (P < 0.05).

Conclusion To strengthen early intervention for pregnancy with severe specific diseases, for the purpose of ensuring the safety of mothers and infants, improving the quality of life for the pregnant women, reducing the burden on pregnancy and saving medical and health costs.To increase the risk awareness and intervention compliance of pregnant women with severe special diseases for the purpose of reducing maternal mortality.