王森, 徐瑞芳, 郭晓虎, 郁晞, 黎桂福, 吴周理. 联合使用PSA等三项指标在前列腺癌早期筛查中的应用[J]. 上海预防医学, 2020, 32(6): 502-505. DOI: 10.19428/j.cnki.sjpm.2020.19170
引用本文: 王森, 徐瑞芳, 郭晓虎, 郁晞, 黎桂福, 吴周理. 联合使用PSA等三项指标在前列腺癌早期筛查中的应用[J]. 上海预防医学, 2020, 32(6): 502-505. DOI: 10.19428/j.cnki.sjpm.2020.19170
shu
WANG Sen, XU Rui-fang, GUO Xiao-hu, YU Xi, LI Gui-fu, WU Zhou-li. Application of PSA and related indicators in early screening of prostate cancer[J]. Shanghai Journal of Preventive Medicine, 2020, 32(6): 502-505. DOI: 10.19428/j.cnki.sjpm.2020.19170
Citation: WANG Sen, XU Rui-fang, GUO Xiao-hu, YU Xi, LI Gui-fu, WU Zhou-li. Application of PSA and related indicators in early screening of prostate cancer[J]. Shanghai Journal of Preventive Medicine, 2020, 32(6): 502-505. DOI: 10.19428/j.cnki.sjpm.2020.19170
shu

联合使用PSA等三项指标在前列腺癌早期筛查中的应用

Application of PSA and related indicators in early screening of prostate cancer

    摘要
  • 摘要:
    目的探讨血清总前列腺特异性抗原(tPSA)、游离前列腺特异性抗原(fPSA)、fPSA/tPSA值以及前列腺癌特异性抗原密度(PSAD)在前列腺癌早期筛查中的最佳鉴别点，从而提升前列腺癌早期筛查的特异性。
    方法通过对前列腺增生组(250例)和前列腺癌组(92例)病例的tPSA、fPSA、fPSA/tPSA及PSAD检测，绘制受试者工作特征(ROC)曲线确定其筛查前列腺癌的最佳截断值，评估其最佳的前列腺癌早期筛查方法。
    结果当tPSA、fPSA/tPSA、PSAD截断值分别取11.3 mg/L、0.16、0.18 mg/(L·cm3)时, 特异度和灵敏度最佳，分别为82.4%和84.2%、76.9%和81.7%、83.1%和80.4%；将tPSA、fPSA/tPSA、PSAD的最佳截断值串联后进行筛查，fPSA/tPSA与PSAD串联后特异度和灵敏度达到最佳，分别为92.4%、81.4%；当tPSA值在4~10 mg/L，PSAD和fPSA/tPSA的最佳截断值为0.21 mg/(L·cm3)和0.15时，特异度和灵敏度达到最佳，分别为84.1%、80.1%和81.0%、80.3%。
    结论联合使用PSA等三项指标早期筛查前列腺癌的效果优于单一指标筛查，fPSA/tPSA与PSAD串联后的特异度和灵敏度可作为最优筛查参考值。

     

    Abstract:
    ObjectiveSerum total prostatic specific antigen (tPSA), free prostatic specific antigen (fPSA), fPSA/tPSA ratio, and prostate cancer-specific antigen density (PSAD) were determined to explore the best identification point, thus improving the specificity of early screening of prostate cancer.
    MethodsThe tPSA, fPSA, fPSA/tPSA, and PSAD of patients with benign prostatic hyperplasia group (n=250) and prostate cancer group (n=92) were tested, and the receiver operating characteristic (ROC) curve was drawn to determine the best cutoff value for the evaluation.
    ResultsWhen the cutoff values of tPSA, fPSA/tPSA, and PSAD were at 11.3 mg/L, 0.16, and 0.18 mg/(L·cm3), respectively, the specificity and sensitivity were the best:82.4% and 84.2% for tPSA, 76.9% and 81.7% for fPSA/tPSA, and 83.1% and 80.4% for PSAD.When the best cutoff values of tPSA, fPSA/tPSA, and PSAD were combined in analysis, the specificity and sensitivity of fPSA/tPSA and PSAD combination showed the best result (92.4% and 81.4%, respectively).When the tPSA value was in the range of 4-10 mg/L, the optimal cutoff values of PSAD and fPSA/tPSA were 0.21 mg/(L·cm3) and 0.15, and the specificity and sensitivity reach the best, which were 84.1% and 80.1%, 81.0 % and 80.3%, respectively.
    ConclusionCombination of tPSA, fPSA/tPSA and PSAD analysis is better than any single of them in early screening of prostate cancer.The specificity and sensitivity of combined use of fPSA/tPSA and PSAD could serve as an optimal screening reference value.

     

    • HTML全文
    • 参考文献(12)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回