日照对早期糖尿病肾病患者血维生素D和尿微量蛋白的影响

蒋小红; 黄珊; 邰筱晨; 汤瑜斌

doi:10.19428/j.cnki.sjpm.2020.19636

日照对早期糖尿病肾病患者血维生素D和尿微量蛋白的影响

The effect of sunshine on blood level of Vitamin D and microalbuminuria in early stage diabetic nephropathy patients

摘要

摘要:
目的评估增加日光照射能否提高2型糖尿病早期肾病患者血25羟维生素D₃(25(OH)D₃)水平以及改善微量白蛋白尿。
方法以2018年1月至2019年5月我院内分泌住院及门诊2型糖尿病患者25(OH)D₃ < 15 mg/L早期糖尿病肾病患者为研究对象，共150例。所有研究对象分为3组：日照组、1, 25(OH)₂D₃组和对照组，每组50例。比较3月后3组血25(OH)D₃水平的变化以及尿白蛋白/肌酐(ACR)的变化。
结果治疗前3组间25(OH)D₃水平、ACR及糖化血红蛋白差异均无统计学意义(P>0.05)。治疗3月后日照组血清25(OH)D₃水平较对照组及1, 25(OH)₂D₃组显著升高；ACR较对照组显著降低，与1, 25(OH)₂D₃组差异无统计学意义。
结论日光照射能够有效提高2型糖尿病早期肾病患者血25(OH)D₃水平以及改善微量白蛋白尿。

Abstract:
ObjectiveTo evaluate the effect of increasing sunshine time or 1, 25(OH)₂D₃ supplement on improving Vitamin D blood level and reduction of microalbuminuria in early stage diabetic nephropathy (DN) patients.
MethodsA total of 150 early stage type 2 DN patients with serum 25(OH)D₃ lower than 15 mg/L were included.The patients were divided into sunshine group (n=50), 1, 25(OH)₂D₃ supplement group (n=50), and control group (n=50).After three-month treatment, serum 25(OH)D₃ level and urinary albumin to creatinine ratio(ACR)were compared among these three groups.
ResultsBefore treatment, there were no differences in serum 25(OH)D₃, ACR, HbA1c among the three groups.After three-month treatment, serum 25(OH)D₃ level was significantly improved in sunshine group, and ACR was reduced significantly in both sunshine group and 1, 25(OH)₂D₃ group.
ConclusionIncreasing sunshine time can improve Vitamin D level and reduce microalbuminuria in early stage diabetic nephropathy patients.

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