Abstract: The center of disease prevention and control (CDC) is an emergency agency with semi-militarized management.It serves like scouts and commandos in handling various public health emergencies, and CDC members are in close contact with pathogens and harmful substances.Due to different nature of public emergencies such as prevention and control of infectious diseases, chemical poisoning, occupational poisoning, natural disasters and food safety accidents, the response measures of CDC emergency team are also different.In handling epidemic emergencies, there are different special requirement for the supplies, including equipment and consumables, used in sampling, disinfection, laboratory tests, and personal protection as well as vaccines and drugs.Therefore, it is necessary to establish a unified modern emergency supply system in CDC at levels of state, provinces, cities and counties.Internet of things + technology will be used to establish a set of intelligent platform for emergency material support in disease prevention and control institutions based on centralized management, combinational use in both peacetime and wartime, and unity and high efficiency.Setting up such an emergency material reserve would not only ensure quick response in emergency but also achieve mobility, cost saving and high efficiency.Combining big data, blockchain technology and smart city construction, we will integrate emergency material support for disease prevention and control in different institutions into the national unified emergency material support system which would ensure that disease prevention and control institutions can effectively handle major public health emergencies.