王嘉行, 殷方兰, 张永, 钟培松. 上海市嘉定区HIV抗体不确定人群流行病学调查及随访研究[J]. 上海预防医学, 2021, 33(2): 124-127. DOI: 10.19428/j.cnki.sjpm.2021.19149
引用本文: 王嘉行, 殷方兰, 张永, 钟培松. 上海市嘉定区HIV抗体不确定人群流行病学调查及随访研究[J]. 上海预防医学, 2021, 33(2): 124-127. DOI: 10.19428/j.cnki.sjpm.2021.19149
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WANG Jia-xing, YIN Fang-lan, ZHANG Yong, ZHONG Pei-song. Epidemiological investigation and follow-up study of indeterminate HIV antibody test results in Jiading, Shanghai[J]. Shanghai Journal of Preventive Medicine, 2021, 33(2): 124-127. DOI: 10.19428/j.cnki.sjpm.2021.19149
Citation: WANG Jia-xing, YIN Fang-lan, ZHANG Yong, ZHONG Pei-song. Epidemiological investigation and follow-up study of indeterminate HIV antibody test results in Jiading, Shanghai[J]. Shanghai Journal of Preventive Medicine, 2021, 33(2): 124-127. DOI: 10.19428/j.cnki.sjpm.2021.19149
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上海市嘉定区HIV抗体不确定人群流行病学调查及随访研究

Epidemiological investigation and follow-up study of indeterminate HIV antibody test results in Jiading, Shanghai

    摘要
  • 摘要:
    目的了解HIV抗体检测产生不确定结果的检出率及人群分布情况，并通过随访复检探讨蛋白印迹试验（WB）带型与HIV感染的关系。
    方法对2013-2017年上海市嘉定区疾病预防控制中心HIV抗体确证检测为不确定结果的样品来源、蛋白印迹试验带型模式的分布及随访结果进行分析。
    结果698份待复测样本经WB试验报告为不确定结果者为151份，占21.63%。对其中100份标本进行随访，随访到50人，随访率50.00%。其中随访结果仍为HIV抗体不确定者28例，占56.00%，随访结果转为HIV抗体确认阴性和HIV抗体确认阳性者都是11例，占22.00%。151份不确定结果中共检测出18种带型，p24、gp160、和gp160p24是最为常见的3种带型，占79.47%。其中带型p24的样本随访结果为HIV抗体不确定者比例最高，达67.86%；带型gp160的样本随访结果为HIV抗体阴性者比例最高，达40.00%；带型gp160gp120p24、gp160p24p17和gp160gp120p66p51的随访结果均转为HIV抗体阳性。
    结论不同人群的HIV抗体不确定检出率存在差异，不同的WB带型阳转率也不尽相同，应加强特殊人群及特定WB带型样本的随访，以期尽早发现HIV感染的病例。

     

    Abstract:
    ObjectiveTo investigate the rate and the population distribution of subjects with indeterminate result of HIV antibody test and to understand the relationships between the western blot(WB)banding patterns and HIV infection through follow-up reexamination.
    MethodsSamples with indeterminate results of HIV antibody test were collected by Jiading Center for Disease Control and Prevention from 2013 to 2017. They were used for analysis of the source, the distribution of Western blotting band pattern and the follow-up results.
    ResultsAmong 698 samples required to be re-tested for confirmation of HIV infection, 151(21.63%)showed indeterminate WB test results. There were 18 types of WB band in 151 HIV antibody-indeterminate samples. The most common band types, accounting for 79.47%, were p24, gp160, and gp160p24. One hundred(among 151)subjects were followed up and the success follow-up rate was 50.00%. Among them, 28(56.00%)samples were still with indeterminate results of HIV antibody, 11(22.00% turned to be negative and 11(22.00%)turned to positive. The follow-up confirmatory tests showed that 67.86% of the samples with p24 band were still with indeterminate results and 40.00% of the samples with gp160 band became HIV antibody-negative. The samples with one of the three band patterns of gp160gp120p24, gp160p24p17 and gp160gp120p66p51 all became HIV antibody-positive.
    ConclusionThe detection rate of indeterminate HIV antibody results varies in different populations. Positive conversion rates with different WB band patterns are different. Follow-up of the populations with specific WB band patterns should be strengthened to detect HIV infection cases as early as possible.

     

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