代谢综合征对大鼠的生殖生育能力的影响

孙宇立; 丁瑜; 钱科蕾; 潘杰; 杨隽; 成雪晴; 洪新宇; 肖萍

doi:10.19428/j.cnki.sjpm.2021.19917

代谢综合征对大鼠的生殖生育能力的影响

Fertility and reproduction in rats with metabolic syndrome

摘要

摘要:
目的通过模型动物，研究代谢综合征（metabolic syndrome，MetS）对于生殖生育能力的影响。
方法采用“自发性高血压大鼠（SHR）给予高脂饲料喂养”的模式，根据MetS判定原则构建MetS模型大鼠。运用MetS模型大鼠进行雌雄1 : 1合笼交配，交配周期2周，自然生育子鼠，分析雄鼠和雌鼠的生殖生育能力指标。
结果SHR大鼠经高脂饲料喂养10周以后，满足MetS筛选条件的雄鼠有16只，雌鼠有15只，成模率为40%和37.5%。MetS雄鼠除了代谢相关指标(血糖、血脂、血压)的异常外，主要是精子活动力明显减弱（P < 0.05）、精子畸形率明显增加（P < 0.01）、交配率明显降低（P < 0.05）。MetS雌鼠除了代谢相关指标的异常外，受孕率和活胎率略低于对照组，但无统计学差异; 仔鼠的窝平均出生体重明显低于对照组（P < 0.05）。
结论通过从交配到自然生产的整个过程的分析，MetS对于大鼠生殖生育能力有明显的影响。

Abstract:
ObjectiveTo study the effect of metabolic syndrome on the fertility and reproduction in model animals.
MethodsThe model of"high fat diet for spontaneously hypertensive rats(SHR)"was adopted to construct the model of metabolic syndrome in rats. The metabolic syndrome model rats were used to mate with male and female 1 : 1 cage, and the mating cycle was 2 weeks.
ResultsAfter the SHR rats were fed a high-fat diet for 10 weeks, 16 males and 15 females met the screening criteria for metabolic syndrome, with the modeling rates of 40% and 37.5%, respectively. In addition to the abnormal metabolism-related indicators(such as blood glucose, blood lipid and blood pressure), the male rats with metabolic syndrome mainly had decreased sperm motility(P < 0.05), increased sperm malformation rate(P < 0.01), and decreased mating rate(P < 0.05). In addition to abnormal metabolism-related indicators, the conception rate and the live fetal rate of the female rats with metabolic syndrome were slightly lower than that of the control group; however, there was no statistical difference. The mean birth weight of the litter was significantly lower than that of the control group(P < 0.05).
ConclusionAccording to the whole process from mating to natural production, metabolic syndrome is determined to have a significant effect on the fertility and reproductive ability of rats.

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