朱韩武, 刘静, 何德彪, 周虹, 郑文, 周亮, 谭徽. 血清抗体检测在一起新型冠状病毒肺炎疫情传播链推断中的应用[J]. 上海预防医学, 2021, 33(3): 192-195. DOI: 10.19428/j.cnki.sjpm.2021.20213
引用本文: 朱韩武, 刘静, 何德彪, 周虹, 郑文, 周亮, 谭徽. 血清抗体检测在一起新型冠状病毒肺炎疫情传播链推断中的应用[J]. 上海预防医学, 2021, 33(3): 192-195. DOI: 10.19428/j.cnki.sjpm.2021.20213
shu
ZHU Han-wu, LIU Jing, HE De-biao, ZHOU Hong, ZHENG Wen, ZHOU Liang, TAN Hui. Application of serum antibody detection in the identification of transmission chain of COVID-19[J]. Shanghai Journal of Preventive Medicine, 2021, 33(3): 192-195. DOI: 10.19428/j.cnki.sjpm.2021.20213
Citation: ZHU Han-wu, LIU Jing, HE De-biao, ZHOU Hong, ZHENG Wen, ZHOU Liang, TAN Hui. Application of serum antibody detection in the identification of transmission chain of COVID-19[J]. Shanghai Journal of Preventive Medicine, 2021, 33(3): 192-195. DOI: 10.19428/j.cnki.sjpm.2021.20213
shu

血清抗体检测在一起新型冠状病毒肺炎疫情传播链推断中的应用

Application of serum antibody detection in the identification of transmission chain of COVID-19

    摘要
  • 摘要:
    目的探讨血清抗体检测在新型冠状病毒肺炎（COVID-19）疫情传播链推断中的应用，为疫情防控提供科学依据。
    方法对确诊病例和密切接触者进行现场流行病学调查，采用实时逆转录聚合酶链反应（RT-PCR）法检测咽拭子、肛拭子标本新型冠状病毒核酸，采集血清进行IgM单独检测和IgM/IgG联合检测。
    结果确诊病例A无明确COVID-19流行病学史; 病例C、D与A同餐同住，且与其他COVID-19确诊病例（H、L）有接触史和聚餐史。病例A新型冠状病毒核酸检测结果阳性，病例C和D均阴性。病例A和C单独IgM检测均阳性，病例D阴性; 病例A、C和D IgM/IgG联合检测结果均阳性。病例C无临床症状，而病例D有临床症状。
    结论血清抗体检测可作为COVID-19传播证据链推断的有效补充，为找寻传染源和完善证据链提供参考依据。

     

    Abstract:
    ObjectiveTo explore the transmission chain of COVID-19 by serum antibody detection, and to provide scientific evidence for the prevention and control of the epidemic.
    MethodsField epidemiological investigation was used to determine the COVID-19 cases and their close contacts. The 2019-nCoV nucleic acid in throat swabs and anal swabs were examined by RT-PCR. Serum specimens were collected for anti-2019-nCoV IgM antibody detection and combined IgM/IgG detection.
    ResultsCase A had no confirmed exposure to COVID-19. However, case C and D had dinner and lived together with case A; they reported contact history and dinner history with other confirmed COVID-19 cases(H, L). Case A tested positive for 2019-nCoV nucleic acid, whereas case C and D were negative. Moreover, case A and C were IgM antibody positive, while case D was negative. Case A, C and D were all positive for combined IgM/IgG. In addition, case D had clinical symptom, while case C did not.
    ConclusionSerum antibody detection can be used as an effective supplement to the inference of transmission chain of COVID-19, which may facilitate determining the source of infection and improving the evidence.

     

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