Objective To describe the current situation of self-stigma in patients with mental disorders and investigate its related influencing factors.

Methods Using cluster sampling method， general situation and self-stigma of 3 926 patients with mental disorders were investigated with a questionnaire.

Results The average total score of stigma in patients with mental disorders was 32.81±14.41. There were statistically significant differences between social factors and occupation， economic status， mental symptoms and behavior involving violence， insight， medication compliance， adverse drug reactions， family monitoring， relationship between guardian and patient， and social participation and social function. There were statistically significant differences between ability factors and occupation， education level， marital status， diagnosis， past accidents and dangerous behaviors， mental symptoms involving violence， insight， medication compliance， disability assessment， implementation of guardianship subsidy measures， family guardianship， relationship between guardians and patients， and social participation and social function. There were statistically significant differences between treatment factors and occupation， marriage， diagnosis， mental symptoms involving violence， insight， medication compliance， adverse drug reactions， family supervision， relationship between guardian and patient， and social participation and social function. According to multiple linear stepwise regression analysis， factors with influence on the total score of stigma， in descending order， were adverse drug reactions， family monitoring， mental status and behavior involving violence， employment， medication compliance， and social function and social participation.

Conclusion Patients with mental disorders have a high score of self-stigma， which is related to adverse drug reactions， family monitoring， mental status and behavior involving violence， employment， medication compliance， and social function and social participation.