新型冠状病毒感染再感染发生率及重症率的回顾性系统分析

石磊; 辛莘; 孙芹; 王媛; 李丹妮; 李科

doi:10.19428/j.cnki.sjpm.2023.23237

新型冠状病毒感染再感染发生率及重症率的回顾性系统分析

Retrospective systematic analysis of incidence and severity of COVID-19 reinfection

摘要

摘要:
目的探讨新型冠状病毒感染（COVID⁃19）再感染的发生与重症情况。
方法通过PubMed、Embase、中国知网、万方医学网，检索新型冠状病毒再感染的相关文献，纳入队列研究、病例报告、横断面研究，利用Revman 5.3.0软件对结果进行分析。
结果共纳入来自 19个国家的52篇文献，文献研究质量评价均为中高等质量。Meta分析结果显示，COVID⁃19再感染发生率为1.9%，95%CI：0.9%~4.7%（P<0.01），医务人员及养老机构人员再感染发生率为13.8%，95%CI：4.8%~34.2%（P<0.01），再感染患者重症发生率为17.3%，95%CI：11.5%~25.9%（P<0.01）。敏感性与发表偏倚分析显示，结果具有较好的稳定性，不存在发表偏倚。
结论再感染发生率相对较高且再感染后重症发生率仍然较高，尽管国内调整了疫情防控政策，但群众应注意做好防护措施，避免再感染及重症的发生。

Abstract:
Objective To investigate the incidence and severity of COVID-19 reinfection.
Methods We searched relevant studies on COVID-19 reinfection， including cohort study， case report， and cross-sectional study in PubMed， Embase， CNKI and Wanfang databases. Revman5.3.0 was used for statistical analysis.
Results A total of 52 studies in 19 countries were included. These literatures showed moderate and high quality. Furthermore， the pooled incidence of COVID-19 reinfection was estimated to be 1.9%（95%CI： 0.9%‒4.7%， P<0.01）， pooled incidence of reinfection among medical workers in hospitals and staff in nursing home was 13.8%（95%CI： 4.8%‒34.2%， P<0.01）， and pooled incidence of critical reinfection was 17.3%（95%CI： 11.5%‒25.9%， P<0.01）.Sensitivity and publication bias analysis showed that the pooled incidence was stable and no publication bias was identified.
Conclusion Incidence and severity of COVID-19 reinfection are both high. Although the prevention and control policy against COVID-19 has been adjusted in China， the public should pay attention to taking protective measures to avoid the reinfection.

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