Abstract:
Objective To investigate the incidence and severity of COVID-19 reinfection.
Methods We searched relevant studies on COVID-19 reinfection, including cohort study, case report, and cross-sectional study in PubMed, Embase, CNKI and Wanfang databases. Revman5.3.0 was used for statistical analysis.
Results A total of 52 studies in 19 countries were included. These literatures showed moderate and high quality. Furthermore, the pooled incidence of COVID-19 reinfection was estimated to be 1.9%(95%CI: 0.9%‒4.7%, P<0.01), pooled incidence of reinfection among medical workers in hospitals and staff in nursing home was 13.8%(95%CI: 4.8%‒34.2%, P<0.01), and pooled incidence of critical reinfection was 17.3%(95%CI: 11.5%‒25.9%, P<0.01).Sensitivity and publication bias analysis showed that the pooled incidence was stable and no publication bias was identified.
Conclusion Incidence and severity of COVID-19 reinfection are both high. Although the prevention and control policy against COVID-19 has been adjusted in China, the public should pay attention to taking protective measures to avoid the reinfection.