Abstract: Objective To investigate the regularity of incidence of the thyroid cancer in Fengxian from 2002 to 2011, in order to provide the basis for prevention and intervention measure. Methods Cases with thyroid cancer in Fengxian from 2002 to 2011 were collected by the Shanghai Cancer Registry Organization. The incidence rate and standardized incidence rate were calculated and analyzed for trends of thyroid cancer incidence in the period of 2002-2011 in Fengxian. Results The standard incidence of thyroid cancer in male and female declined from 1.09/10 000 and 3.40/10 000 in 2002 to 13.28/10 000 and 28.37/10 000 in 2011, and increase per year was 32.02% in male and 26.58% in female during this ten years. The average increase of total standard incidence of thyroid cancer was 25.76%.During the past 10 years, the incidence of thyroid cancer was increased with an upward trend, especially in females; it was in the first place of female cancers. The male to female ratio of incidence was 0.30:1.The highest incidence of thyroid cancer was seen in male and female belonging to the age group of 20 to 64 years. The papillary thyroid cancer (PTC) was found in 76.56% patients of thyroid cancer. Conclusion The standard incidence of thyroid cancer has increased in general in Fengxian from 2002 to 2011. As the papillary thyroid cancer is the highest proportion of thyroid cancer, we need to actively seek its relevant risk factors. The results indicate that it is an important public health task to prevent and control thyroid cancer in people at the age of 20-64 years.