Abstract: Objective To analyze the detection of ESBLs-producing Escherichia coli by urine culture and its related risk factors in inpatients with urinary tract infection in community hospital.Methods Retrospective analysis was done on clinical data from 169 inpatients with urinary infection whose midstream urine culture was discovered with Escherichia coli, then ESBLs were detected in all of the patients, and risk factors were analyzed by logistic regression analysis in urinary tract infection caused by ESBLs-producing Escherichia coli.Results Univariate analysis showed that the differences were found to be statistically significant in benign prostatic hyperplasia, number of hospitalization days, indwelling catheterization, use of the third generation cephalosporins between ESBLs group and non ESBLs group (P<0.05). Logistic regression analysis showed that indwelling catheterization (OR=4.546) and use of the third generation cephalosporins (OR=4.361) were risk factors for urinary infection by ESBLs-producing Escherichia coli.Conclusion Patients who used catheterization and the third generation cephalosporins were more susceptible to ESBLs-producing Escherichia coli, so we should pay more attention to patients with the risk factors mentioned above, use catheterization carefully and the third generation cephalosporins rationally, so as to reduce the incidence of urinary tract infection by ESBLs-producing Escherichia coli.