Abstract: Objective To observe the effect of combined treatment of small doses simvastatin and irbesartan for carotid intima-media thickness(IMT) in patients with mild-to-moderate hypertension and normal serum lipid level. Methods A total of 124 patients with mild-to-moderate hypertension and normal serum lipid level were randomly divided into the observation group (simvastatin combined with irbesartan) of 64 cases and the irbesartan group of 60 cases. Three months were as a course of treatment,and each patient in both groups received two courses;IMT,blood pressure and blood lipids were compared in the two groups before and after treatment. Results After treatment of six months,systolic and diastolic blood pressure, IMT in both groups were significantly decreased, and IMT in the observation group was lower than that in the control group (all P<0.05). In observation group, TC and LDL-C levels were significantly decreased, and HDL-C level was significantly increased (all P<0.01). Conclusion Besides lowering blood pressure and blood lipids levels, combined treatment of small doses simvastatin and irbesartan has good reverse effect on increased IMT and improves carotid atherosclerosis in patients with mild-to-moderate hypertension and normal serum lipid level.