Abstract: Objective To investigate the changes of the level of serum uric acid (SUA) in hypertension patients with target organ damage and its clinical significance. Methods From January 2013 to December 2014,a series of 1320 cases of primary hypertension in our hospital were included as a case group.According to the cases with or without target damage,they were allocated into two groups:organ damaged and organ non-damaged,with 100 healthy cases as control group.The SUC levels deteced were compared between the groups. Results Of the 1320 cases with target organ damage, 1091 cases(82.65%) were found to have level of SUA significantly higher than that in control group (P<0.05);SUA level in organ damaged group was higher than that in non-damaged group (P<0.05);SUA level in cases with 3 or more target organs damage was significantly higher than that in cases with 1 and 2 target organs damage(P<0.05),indicating a significant positive correlation.The age of hypertensive patients,and their SUA TC,TG,LDL-C,BUN,Cr,FBG,LVMI,SBP,DBP(r>0, P<0.05), were positively correlated with SUA, which was significantly negatively correlated with HDL-C (r<0, P<0.05). Multivariate logistic regression analysis showed that the hypertension course(OR=5.669), SBP(OR=4.323),DBP(OR=4.215),LVMI(OR=4.323),SCR(OR=4.215) and target organ damage(OR=7.145) all had remarkableimpact with SUA levels in patients(P<0.05). Conclusion The level of SUA in hypertension is generally elevated and closely related with target organ damage and glucolipid metabolic disorder, and the course of hypertension.