Abstract: Objective To explore the clinical effect and safety of using masks with reservoir fog cans for drug administration, nasal inhaled fluticasone propionate aerosol synchronization for treatment of children allergic asthma accompanying with allergic rhinitis.Methods Eighty cases of allergic rhinitis accompanying with mild, moderate and severe persistent asthma were randomly divided into the experimental group and the control group. the experimental group were given the inhaled fluticasone propionate aerosol 200 μg /d via face mask storage tank nasal mist; the control group were given the orally inhaled fluticasone propionate aerosol 200 μg /d combining with the use of fluticasone propionate nasal spray 200 μg /d. The rhinitis symptom score, childhood asthma control test (C-ACT) score and monitoring morning peak expiratory flow (PEF) was compared between the two groups.Results During 16 weeks clinical observation, the rhinitis symptom score and asthma symptom scores were significantly decreased both in the experimental group and the control group (F=71.22~277.41,P<0.001 for the two groups).The rates of PEF (L/min) in the experimental group and in the control group were increasing gradually before and after the treatment; however, the difference was only significant in the experimental group(F=4.79,P<0.009), not in the control group (F=1.49,P=0.19).The rate of side effect was significantly lower in the experimental group then in the control group (F=4.79，P＜0.009). Furthermore, the dose of hormone used in the experimental group was only 50% as the one used in the control.Conclusion The mask type storage fog cans by nasal inhalation fluticasone propionate aerosol can effectively control children with allergic rhinitis and asthma with higher compliance, fewer side effects and reduced drug dosage etc, which is suitable for mild to moderate persistent asthma complicated with allergic rhinitis in children.