Abstract: Objective To explore the related factors of colorectal polyps. Methods Participants were divided into polyps group and control group according to colonoscopy. The possible risk factors were investigated by questionnaire. Logistic regression analysis was conducted in order to explore the related factors of colorectal polyps. Results A total of 252 participants (154 in polyps group, 98 in control group) were enrolled in the current study. Multivariate Logistic regression analysis showed that those with higher odds ratio of colorectal polyps were among male (OR:2.65, 95% CI:1.17-6.00) and obesity (OR:4.80,95%CI:1.16-9.94), among those with family history of colorectal polyps(OR:10.19, 95%CI:1.19-17.26), and those with high proportion of fat intake(OR:3.24, 95%CI:1.46-7.20). Conclusion Male, obesity, family history of colorectal polyps and high proportion of fat intake are the related factors of colorectal polyps. And investigation by related factors questionnaire facilitates the targeted screening of colorectal tumors.