Abstract: Objective To investigate death rates for injury and poisoning in Rugao City from 2008 to 2012, so as to provide advisable evidence for government to institute injury prevention strategy. Methods The mortality data on injury and poisoning from 2008 to 2012 in Rugao City was analyzed with descriptive statistics by means of population data offered by Public Security Bureau and DeathReg 2005. Results From 2008 to 2012, the average annual mortality rate of injury and poisoning was 50.93 per 100,000 in Rugao City, and the standardized mortality was 37.76 per 100,000, ranked fifth in all causes of death, while the potential years of life lost (PYLL) ranked second. The total mortality rate of injury and poisoning was higher in male than in female. The first four death causes in rank order of death cause for injury and poisoning were vehicle accident, accidental falling, drowning, and suicide. The mortality rate declined with age before 15 years old, then the mortality rate rose with age. The vehicle accident ranked first for PYLL, while the accidental mechanic asphyxia ranked first for average years of life lost (AYLL). Conclusion Health education for injury prevention must be strengthened. Powerful and effective measures must be taken to decrease the mortality for injury and poisoning according to the characteristics of injury and poisoning death.