Abstract: Objective To explore the relationship between neonatal cord blood IgE value and their parents allergies as well as birth status. Methods The pregnant women in labor were investigated by questionnaire and detected for blood 25-hydroxy vitamin D₃. The neonatal cord blood was collected for detection of IgE in childbirth, and the birth status was traced and recorded. Statistical analysis was done on the correlative factors of umbilical cord blood IgE. Results The facts that mother had history of allergic diseases(OR=1.65), neonatal birth weight was too large(OR=3.36), baby was male (OR=1.90), and born with asphyxia(OR=2.88) were all associated with the positiveness of cord blood IgE (P<0.05). Conclusion The allergy history of mother is a risk factor for the rise of cord blood IgE, so measures for eczema prevention should be well taken for her baby.