Abstract: Objective To analyze the characteristics of anaphylactic rash after vaccination in Ouhai District of Wenzhou City during 2008-2013. Methods Data on anaphylactic rash cases reported during 2008-2013 were collected through the national AEFI information management system.And descriptive epidemiologic methodology was used in this study. Results A total of 111 anaphylactic rash cases were reported in Ouhai District during 2008-2013,the reported incidence rate of anaphylactic rash were 3.58 per million doses. The ratio of male-female was 1.27:1. Cases of ≤ 1 year old accounted for 65.77%. Those without fever accounted for 75.68%. The number of the reports for the third quarter of the year accounted for 41.44% of the total. The cases of anaphylactic rash mostly occurred within 24 h after immunization(81.08%).The top three vaccines reported in occurrence of rash were measles and rubella attenuated live vaccine(35.14%), diphtheria, tetanus and acellular pertussis combined vaccine(18.92%),and A(H1N1)influenza vaccine(5.41%).The reported rates for the top three vaccines were 115.85,29.33,13.07 per million doses for 7-valent pneumococcal polysaccharide conjugate vaccine,measles and rubella combined attenuated live vaccine, A(H1N1) influenza vaccine,respectively. Conclusion Differential diagnosis of anaphylactic rashes needs to be more stressed.Most anaphylactic rash were reported in the expected range,but still monitoring analysis on incidence of allergic rash should be enhanced.Vaccines with higher incidence of rash reported should be further studied and analyzed.