Abstract: Objective To learn the intervention effectiveness on HIV infected men who have sex with men (MSM) and to provide reference for follow-up management. Methods All HIV-infected MSM who were reported from January 1, 2008 to December 31, 2015 and followed-up for one year in Linhai City were enrolled. High risk sexual behaviors and changing status of spouses/sex partners were analyzed to assess the effective of intervention. Results Among the 96 patients who were followed up for one year, 40.6% were aged 20-29 years, 54.2% had an education of high school or above, 60.4% were unmarried. 95.8% participants received ART with a viral inhibition ratio of 98.9%. Before and after one year's follow-up, the proportion of high-risk sexual behavior declined from 44.8% to 4.2%. The proportion of HIV positive status of spouses was higher in unmarried HIV infected MSM than in married HIV infected MSM (2.9% vs 57.1%). Conclusion High risk sexual behaviors of HIV-infected MSM in Linhai City declined dramatically after one-year follow-up and intervention. The proportion of married HIV infected MSM who inform their spouses of their HIV infection status and the proportion of HIV positive status of their spouses is higher than unmarried HIV infected MSM. HIV-related health education and follow-up management should be enhanced, particular to the HIV infected individuals who still have risky behavior to reduce the risk of HIV second generation transmission of HIV infected MSM.