Abstract: Objective To explore the mechanism for sustainable community tuberculosis control mode in mega-cities by analyzing and evaluating the implementation of standardized management practices in Putuo District, Shanghai.Methods Quantitative research including analyzing data obtained from national TB registration system and a questionnaire survey in 10 community health service centers was conducted.Results Standardized community TB management practices in Putuo District was effectively implemented, and the standardized management series manuals were supported by community physicians and pulmonary TB patients. Newly registered TB rate declined from 2011 to 2015; the cure rate of new smear positive TB patients was 85.00%, overall tracking rate of suspected or diagnosed TB patients was over 90.00%; screening rate of close contacts with TB patients was 100.00%; standardized manuals were distributed to 100.00% patients, and was utilized by 90.87% of them; 100.00% community physicians were satisfied with the standardized manuals, of whom 40.98% scored the highest satisfaction level.Conclusion Community tuberculosis control mode was effectively implemented in Putuo District through process management, job content quantification, evaluation system establishment, and high quality health intervention.