Abstract: Objective To explore the clinical value of conization of cervix in patients of high risk type CIN II、CIN III cervical intraepithelial neoplasia.Methods Patients who received cervix biopsy and conization were retrospectively analyzed.Among them 51 patients were of high risk CIN and had received conization of cervix in our hospital from January 1st, 2006 to August 30, 2008 were recorded.Results The patients of high risk usually had no clinical symptoms.The mean age in this study was 38.47 years.Of the 51 patients, 35 patients (68.63%) had the same pathological diagnosis between cervix biopsy and conization.The pathological diagnosis of 13 patients (25.49%) were degraded and 3 patientes (5.88%) were upgraded.0ne invasive cancer was found.48 patients' (94.12%) cervix cutting edge were negative, others were positive.21 patients infected by HPV turned negative after conization.Conclusion Correct conization method could cure the high risk CIN.While patients tend to become younger and younger they could still retain their normal endocrine, sexual life and breeding function.Conization of cervix is a nonalternative method in diagnosis and treatment of high risk model CIN and can decrease the infection of HPV.It is necessary in screening cervical erosion patients in OPD and follow-up visit after conization of cervix.