Abstract: Objective To analyze the effect of community intervention on urine microalbumin and creatinine ratio (ACR, mg/g) and glomerular filtration rate (GFR) of diabetic nephropathy (DN) patients and provide a reference for prevention and control of DN in community.Methods The microalbuminuria screening positive patients with diabetes (183 cases) were randomly divided into observation group (94 cases) and control group (89 cases), and two groups were re-divided into microalbuminuria and macroalbuminuria subgroups. By means of self-management group activities, interventions were taken in patients with DN in community.After two-year follow up the effect of intervention was assessed.Results Before community intervention, there was no significant difference between the two groups in clinical indicators, such as ACR, GFR and so on. After community intervention, significant differences were found in ACR between the two subgroups of diabetic nephropathy with microalbuminuria. There were no significant differences in ACR and GFR between the two subgroups with macroalbuminuria.Conclusion Community intervention measures cannot significantly improve the renal function of DN patients in macroalbuminuria stage, but can significantly reduce the ACR of patients with microalbuminuria. Early self-management group activities in the community can delay the progression of DN in patients with microalbuminuria.