Abstract: Objective To investigate the efficacy and safety in different doses of atorvastatin for elderly hyperlipidemia.Methods A total of 153 elderly patients with hyperlipidemia were included, who were randomly divided into two groups. Group A (n=79) received 10 mg/d atorvastatin, and group B (n=74) 20 mg/d. Before and after treatment of 2 weeks, 8 weeks, were checked the level of blood lipid, functions of liver and kidney, creatine kinase, creatine kinase isoenzymes.Results After treatment, the level of TC (cholesterol) was reduced by 19.6% (A) and 20.0% (B) respectively in the two groups. LDL-C (low density lipoprotein cholesterol) decreased by 17.4%(A) and 20.1% (B) respectively in the two groups. The level of TC, LDL-C in the two groups showed no difference after treatment(P<0.01).The medicine was not found to cause adverse effect in liver and kidney function and myolysis in the two groups(P>0.05). After taking medicine,The level of uric acid(UA) was decreased in group A (P<0.01). There was no difference in the two groups (P>0.05).Conclusion Oral administration of lower doses of atorvastatin not only lowers the lipid in elderly patients, but also lowers the blood uric acid. And administration of lower and higher doses of atorvastatin are both effective and safe for elderly hyperlipidemia.