Abstract: Objective To investigate the clinical efficacy of gonadotropin-releasing hormone analogue (GnRHa) combined with LNG-IUS in the treatment of adenomyosis. Methods Seventy patients with adenomyosis were randomly divided into observation group (n=34,treated by GnRHa combined with LNG-IUS) and control group (n=36, treated by only LNG-IUS). After treatment were compared the improvement of uterine volume, dysmenorrhea and menorrhagia and other symptoms in the two groups. Results After treatment, the uterine volume, dysmenorrhea severity score and menstrual flow in observation group were significantly lower than those in control group(P<0.05); during follow-up time, there occurred 7 cases(20.58%) of dripping vaginal bleeding and 4 cases(11.76%) of decyclization in control group,while in observation group there was none of occurrence. Conclusion GnRHa combined with LNG-IUS is of better clinical efficacy in the treatment of adenomyosis than LNG-IUS used alone.