Abstract: Objective To analyze high-risk pregnancy and decrease the incidence of high-risk pregnancy and the death rate of pregnant women and infants. Methods In Pudong New Area of Shanghai, a series of 2 060 pregnant women under system management were screened for high-risk pregnancy, of whom 997 under 2004-2006 system management were allocated into group A and 1 063 under 2007-2009 system management into group B. Results In group A, the incidence of high-risk pregnancy was 20.3%, and the rate of cesarean section 64.4%.The first 4 high-risk factors were positive antigen of hepatitis B, abnormal fetal position for more than 36 weeks during pregnancy, experience of cesarean, abortion for more than twice.In group B, the incidence of high-risk pregnancy was 27.1%, and the rate of cesarean section 70.1%.The first 4 high-risk factors were experience of cesarean, positive antigen of hepatitis B, abortion for more than twice, abnormal fetal position for more than 36 weeks during pregnancy. Conclusion With the increase in cesarean section rate, high-risk pregnancy is increased.Only through necessary interventions can we decrease the cesarean section rate and high-risk pregnancy and ensure the security of mother and baby.