Abstract: Objective To investigate the nosocomial infection risk factors on rheumatoid arthritis.Methods This observation was a lengthways retrospective study,focusing in the inpatients in Guanghua hospital from June 2008 to September 2010;their messages and data were studied including gender,age,duration,medication,and infection status.Results A total of 1020 patients were investigated, of whom 824 were female and 196 male,their age being 17-92 years old and the average age 48 years old, with 316 cases developing nosocomial infection.The infection rate was 30.98%.Thirty four cases were multi-site infections,and 32 cases had two kinds of infection,2 cases had three kinds of infection.The comparations between infection and non-infection groups in peripheral blood leukocytes count,plasma hemoglobin,C-reactive protein,gender,the dose of steroid and accompany diseases were significantly different(P<0.05).Conclusion Multi-factor regression analysis showed that peripheral blood leukocytes count,plasma hemoglobin,C-reactive protein,gender,the dose of steroid and accompanied diseases were the risk factors for nosocomial infection in RA.The nosocomial infection rate in RA was much higher than average nosocomial infection rate both at home and abroad.