Abstract: Objective To investigate the recent and long-term development of tuberculosis in patient and the influencing factors of fatality rate. Methods Historical cohort, history review, cause of death information query and questionnaire survey were used to investigate TB treatment outcome, population and characteristics of social economy, influence factors and so on, and calculated for independent death risk factors using the Cox logistic regression multivariate model. Results With two to six years of follow-up, the total mortality of patients with tuberculosis was 16.0%, and the average age of death was 70.9 years,mortality directly from tuberculosis was 3.5%,which was 21.9% of the total deaths.Age,sputum smear-positiveness, haemoptysis were risk factors for early death. Conclusion TB control work should be cooperated with clinical department. Factors with TB such as age, haemoptysis, sputum smear-positiveness especially the risk of death must be concerned for patients within a year after tuberculosis diagnosis so as to improve survival rate.