Abstract: Objective To analyze the years of life lost (YLL) and disability adjusted life year (DALY) contributed to stroke in Xuhui District of Shanghai. Methods The death data of household registration during 1995 to 2012 were collected by Xuhui District death surveillance system. Years of life lost was estimated by formula, years of lived with disability and disability adjusted life year was estimated by indirect way. Results From 1995 to 2012, the average YLLs per thousand people of ischemic and hemorrhagic stroke were declined year by year and the lost in male was higher. The average DALYs per thousand people in stroke patients with sequela were higher (7.53) than those without sequela(5.51). DALYs contributed to stroke sequel rose slightly in the male. Conclusion Compared with the global average, disability adjusted life year of stroke is lower in Xuhui District. The risk of patient dying directly from stroke is reducing, but more attention should be paid to the mortality risk of stroke and measures should be taken to control the growing trend.