Abstract: Objective To analyze the death causes of malignant tumors among residents in Ouhai District of Wenzhou City and provide basis for formulating targeted intervention. Methods The causes of death from 2010 to 2012 were classified according to International Classification of Diseases (ICD-10) and statistically analyzed by the death cause statistical software DeathReg 2005, Excel, and SPSS13.0. Results The annual average mortality of malignant tumors among residents in Ouhai District was 150.41/100 000, the standardized mortality rate was 130.02/100 000. The mortality of malignant tumors was 197.48/100 000 in males and 101.93/100 000 in females, and there was significant gender difference. The top five death causes of malignant tumors were lung cancer, hepatic carcinoma, gastric cancer, colon-rectum-anus cancer, and esophagus carcinoma. The malignant tumor death causes in different age groups were different,and the mortality rate rose with the increase of age.The potential years of life lost(PYLL) of malignant tumor death was 14 634.5 person-years.The average years of life lost(AYLL) and PYLL rate were 8.01 years/person and 12.05‰, respectively. Conclusion The first cause of death among residents is malignant tumor in Ouhai District of Wenzhou City.According to characteristics of different tumors for different population,comprehensive intervention measures should be implemented to reduce the morbidity of malignant tumors.