Abstract: Objective To investigate the effect of community-based comprehensive intervention on improving residents' knowledge, attitude and behaviors in terms of stroke prevention.Methods By means of stratified sampling, 120 resident population were randomly selected from Xietu Neighborhood of Shanghai. Demographic characteristics, prevalence of stroke, knowledge, attitudes and behaviors related to stroke prevention were investigated through baseline survey. After 3-month interventions, end stage survey was conducted to assess the effects of the interventions by measuring the changes of the related indicators as mentioned above.MethodsWith intervention, the residents' knowledge and attitude on stroke prevention was raised. The number of the residents was increased participating in prevention, education and counseling activities on stroke prevention and those who voluntarily went to hospital for early screening on stroke were increased, too.Conclusion Community-based comprehensive interventions could be effective in improving residents' knowledge, attitudes and behaviors on stroke prevention. Conducting community intervention on stroke is necessary.