Abstract: Objective To investigate the survival status of females with breast cancer and explore main factors affecting their life quality.Methods By means of simple random sampling, female patients with breast cancer were selected for questionnaire investigation from the Cancer Registration and Report System of Jiading District. The investigation covered basic conditions, ill information and evaluation of patients' quality of life by FACT-B Scale of Chinese version.Results The total score of quality of life was 109.03. The scores of physical wellbeing, social/family wellbeing, emotional wellbeing, functional wellbeing and additional concerns were 24.61, 21.34, 19.13, 16.81 and 27.14, respectively, in which the functional wellbeing score was relatively lower and additional concerns score relatively higher. Multi-factor analysis indicated that self-evaluation on marriage quality and the times of stress events during the past 5 years were the main factors which affected the total score of quality of life.Conclusion The total quality of life in females with breast cancer in Jiading District is in good situation. And it was found in the investigation that marriage quality and stressful events were major factors affecting their quality of life.